Genomic Integrity

Members of this program focus their research on mutagenesis, mechanisms of DNA repair, cell cycle control, and their impact on genomic integrity and cancer.

Within this program, members are organized into five thematic areas with overlapping research interests:

  • Basic mechanisms of DNA repair and replication
    • Telomere structure and function
    • Mechanisms of homologous recombination
    • Mechanisms for preserving stem cell genomic integrity
    • Cell cycle control
    • Intersection between cell cycle regulation and circadian rhythm
  • Fanconi anemia
  • Head and Neck Cancer
  • Brain tumors (predominantly glioblastoma)
  • Melanoma
Program Co-Leaders:
Peter J Stambrook, PhD, is a leading figure in the mutagenesis, DNA repair and cell cycle control community. He leads an NIEHS-funded training program titled, “Environmental Carcinogenesis and Mutagenesis”, and is past president of Environmental Mutagenesis and Genomics Society and President-elect of the Society for Experimental Biology and Medicine.
https://med.uc.edu/molgen/molgen-directory/faculty-directory/Index/Pubs/stambrpj
Carolyn Price, PhD, is internationally recognized as a leader in the field of telomere structure and function, which plays a key role in both cancer prevention and development. She also serves as co-director and mentor for the NCI-Funded T32 Training Program in Cancer Therapeutics, and has published extensively on model organisms such as Oxytricha and tetrahymena, as well as mammalian systems.
https://med.uc.edu/cancerbiology/labs/price-laboratory/home