LastFirstDegreeAffiliationProgramResearch Interests
Abdel-MalekZalfaPhDUCCancer EtiologyPrevention of UV radiation-induced melanoma formation; first to demonstrate MC1R activation in tanning exposure to UV; first to develop a topical agent for melanoma prevention.
AdamsDeniseMDCCHMCMolecular TherapeuticsVascular anomalies, rare vascular malignant tumors, vascular tumors, edothelial cell biology, mTOR pathway and disease and outcome studies. As medical director of the HMVC, the program has expanded to include complicated vascular anomaly patients from all over the United States and World
AndreassenPaulPhDCCHMCMolecular & Cellular BasisFanconi Anemia; cell cycle check points; genetic instability; replication stress; relationship of DNA repair and chromatin; mitosis; cell biology
BahassiEl MustaphaPhDUCCancer EtiologyIdentification and characterization of genetic determinants of brain tumors resistance to EGFR therapy. Development of non-invasive biomarkers to monitor brain tumor dynamics. Genomic instability, DNA Damage Checkpoint and Repair mechanisms for Therapeutic Targeting of cancer.
Ben-JonathanNiraPhDUCMolecular & Cellular BasisRoles of prolactin, estrogens, and endocrine disruptors in breast cancer and obesity.
BiroFrankMDCCHMCCancer EtiologyGenomic and proteomic biomarkers; environmental factors in breast cancer.
BleesingJackMD, PhDCCHMCCancer EtiologyImmune System Disorders (e.g. Primary Immunodeficiency Disorders) and associated risks of cancer developement, as well as stem cell transplantation for those disorders
CancelasJoseMD, PhDHoxworthMolecular & Cellular BasisHematopoietic stem cell proliferation and differentiation
CasperKeithMDUCCancer EtiologyHead and neck cancer
CecilKimPhDCCHMCMolecular TherapeuticsMR spectroscopy and imaging; evaluating the effects of environmental neurotoxicants and radiation.
ChenJianjunPhDUCMolecular & Cellular BasisConducts basic cancer research to better understand the pathological mechanisms underlying the start, progression, and drug response to acute leukemia.
ChowLionelMD, PhDCCHMCMolecular & Cellular Basiscellular origins and molecular underpinnings of high-grade gliomas in order to design and test novel therapies
ColeyBrianMDCCHMCMolecular TherapeuticsRadiologist-in-Chief, Department of Radiology.
CottonSianPhDUCCancer EtiologyExecutive director of the UC Center for Integrative Health and Wellness; Anxiety, depression, HIV, cancer and asthma, with a particular focus on the impact of medical conditions on psychological and social functioning.
Czyzyk-KrzeskaMariaMD, PhDUCMolecular & Cellular BasisMolecular mechanisms in renal cancer von Hippel-Lindau tumor suppressor autophagy microRNAs hypoxia regulation of gene expression
DaikokuTakikoPhDCCHMCMolecular & Cellular BasisEndometrial cancer and ovarian cancer initiation; molecular and genetic clues to embryo-uterine interactions during implantation
DasguptaBiplabPhDCCHMCMolecular & Cellular BasisIntegration of metabolic and signaling pathways in neural cells including neural and brain cancer stem cells.
DesaiPankajPhDUCMolecular TherapeuticsPharmacokinetics, Pharmacodyanmics and Drug Metabolism/experimental therapeutics/development of oncotherapeutics
DriscollJamesMS,PhDUCMolecular TherapeuticsCell signaling pathways and cell-to-cell interactions in the tumor microenvironment.
DrissiRachidPhDCCHMCMolecular & Cellular BasisDNA repair and cancer.
DuChunyingPhDUCMolecular & Cellular BasisApoptosis proteins in the modulation of DNA repair and check point control, and in the suppression of tumor development.
EhrlichShelleyMD,ScD,MPHCCHMCCancer EtiologyOb/Gynecologist; environmental, pre- and perinatal epidemiologist.
FichtenbaumCarlMDUCCancer EtiologyClinical research in infectious diseases, HIV in particular; osteomyelitis; antiretroviral therapy.
FilippiMarie-DominiquePhDCCHMCMolecular & Cellular BasisMolecular mechanism of hematopoietic cell migration, including neutrophils and hematopoietic stem cells in physiological settings; identification of new molecular targets of potential therapeutic importance.
GeigerHartmutPhDCCHMCMolecular & Cellular BasisHematopoietic stem cells; genetics; aging/longevity; plasticity of stem cells; mobilization; DNA-repair
GellerJamesMDCCHMCMolecular TherapeuticsDevelopmental therapeutics; renal / liver / retinoblastoma / neuro-oncology; Use of biological response modifiers in combination with conventional chemotherapeutics
GreisKenPhDUCMolecular & Cellular BasisTechnology development and the application of mass spectrometry to the understanding of biological systems.
GrimesH. LeightonPhDCCHMCMolecular & Cellular BasisTranscriptional control of hematopoiesis and cancer
GrimleyMichael SMDCCHMCMolecular & Cellular BasisBone marrow transplantation for primary immunodeficiencies; cord blood transplants; leukemia
GuanJun-LinPhDUCMolecular & Cellular BasisSignaling pathway disruption in cancer; identification of new signaling molecules and pathways in cell migration, angiogenesis and metastasis; and role of autophagy in breast cancer and other developmental and disease processes.
HerzogThomasMDUCMolecular TherapeuticsOvarian Cancer, Clinical Trials, Drug Discovery, Transitional Ovarian Cancer
HoShuk-MeiPhdUCMolecular & Cellular BasisRole of hormones and endocrine disruptors on disease development including tumorigenesis in the prostate, ovary, endometrium and breast; impact of heavy metals, oxidative stress and inflammation to carcinogenesis; discovery of biomarkers for cancer detection and patient classification, and mechanism-based drug development.
HuangGangPhDCCHMCMolecular & Cellular BasisOur research interest is the crosstalk and cooperation between transcription factors and histone modifiers.
HuiDavidPhDUCCancer EtiologyGenetic factors regulating cholesteraol transport, metabolism and absorption.
JaechkeAnjaPhDUCMolecular & Cellular BasisRole of stress-activated protein kinases in metabolic signal transduction; role of JNK pathway in the control of metabolic diseases.
JodeleSonataMDCCHMCMolecular TherapeuticsBone marrow transplantation
KalfaTheodosiaMD, PhDCCHMCMolecular & Cellular BasisBasic science researcher studying signaling mediated by Rho GTPases (small G proteins that regulate actin mechanics and reactive oxygen species (ROS) production in cells) in red blood cell (RBC) development, morphology, and deformability.
KalinTanyaMD, PhDCCHMCMolecular & Cellular BasisTranscriptional regulation of tumorigenesis. Role of microenvironment in tumor progression and metastasis.
KhanSohaibPhDUCCancer EtiologyRole oncogenes play in cell differentiation; cellular cholesterol synthesis; Role of insulin in regulation of glycogen phosphorylase gene
KimKyoungHyunPhDUCMolecular & Cellular BasisStudy of fundamental mechanisms in human carcinogenesis using an integrative approach including bioinformatics, proteomics and murine models of human cancers for improved therapeutic applications and cancer prevention
KomurovKakajanPhDCCHMCMolecular & Cellular BasisThe primary focus of my research is on gaining insight into the targetable vulnerabilities of cancers. Our approach is to develop and make an extensive use of predictive and descriptive computational techniques to query the molecular mechanisms that contribute to tumorigenesis of different cancers, followed by extensive biochemical validations. In addition, our lab is also interested in developing new integrative methods for repositioning of clinically available drugs to the therapy of different cancers.
KopanRaphaelPhDCCHMCMolecular & Cellular BasisNotch signaling; kidney organogenesis; skin organogenesis; TSLP signaling in cancer
KovallRhettPhDUCMolecular & Cellular BasisNotch receptor signaling
LangevinScottPhD, MHAUCCancer EtiologyMolecular epidemiology of cancer; development of epigenome-wide association study methodologies for application to cancer, aging or environmental research. Cancer-associated epigenetic alterations, genetic/epigenetic-environment interactions, identification and evaluation of diagnostic and prognostic biomarkers, and the epidemiology of head and neck cancer.
LeeJoo-YoupPhDUCMolecular TherapeuticsMy lab is currently generating very promising results with a drug delivery system which has a novel targeted and controlled drug delivery system for cancer therapeutic treatments as a first application.
LeungYuet-Kin (Ricky)PhDUCMolecular & Cellular BasisEstrogen signaling in hormone-related cancers; exposure to hormone or endocrine disruptors during early life stage on reprogramming disease/cancer risk and its underlying epigenetic modulation.
LowerElyseMDUCMolecular TherapeuticsBreast cancer oncologist
LuRichardPhDCCHMCMolecular & Cellular BasisChromatin remodeling and epigenetic control of glial development and myelination; Acute and chronic demyelinating injury and myelin repair; Molecular and cellular control of brain tumor formation
Mahabee-GittensE. MelindaMDCCHMCCancer EtiologyPediatric secondhand smoke exposure reduction; parental tobacco cessation; adolescent tobacco prevention
MahoneyMaryMDUCCancer EtiologyDirector of Breast imaging and radiology
MalikPunamMDCCHMCMolecular & Cellular BasisGenetic alterations in treatement of sickle cell disease.
McCormackFrankMDUCMolecular TherapeuticsStructure and function of pulmonary surfactant proteins. Mechanisms of pulmonary fibrosis.
MedvedovicMarioPhDUCMolecular & Cellular BasisDevelopment and application of new statistical and computational procedures for the analysis of complex genomic, functional genomic data. Developmenyt of protocols for analyzing microarray data, and the development and application of unsupervised statistical learning approaches based on the Bayesian infinite mixture model.
MeeteiRuhikantaPhDCCHMCMolecular & Cellular BasisMy research focuses on identifying and characterizing proteins comprising the Fanconi anemia core and Bloom syndrome complexes which are associated with chromosome instability, highly elevated cancer incidence and hypersensitivity to variety of genotoxic drugs
MehtaParindaMDCCHMCCancer EtiologyChildhood acute myeloid leukemia; Hematopoietic stem cell transplantation
MellerJarekPhDUCCancer EtiologyDevelopment and application of computational approaches for data mining, analysis and knowledge extraction from biomedical data using structural bioinformatics, computational genomics and systems biology. Methods combining docking simulations, chemical similarity and toxicogenomics to predict activity of environmental factors and other small molecules. Development of novel methods for analysis and predictions of protein interactions, including those for membrane proteins, and for model quality assessment.
MerinoEdwardPhDUCMolecular TherapeuticsNew Therapeutics, DNA Damage
MizukawaBenjaminMDCCHMCMolecular & Cellular BasisPrimary basic and translational research focus on novel therapies for pediatric leukemia
MorrisJohnMDUCMolecular TherapeuticsLung cancer; phase I and experimental therapeutics
MullinsEricMDCCHMCMolecular & Cellular BasisThe interplay between the hemostatic system and the immune system in the setting of inflammatory diseases and infection.
MulloyJamesPhDCCHMCMolecular & Cellular BasisGenetic instability and acute myeloid leukemia (AML);
NassarNicolasPhDCCHMCMolecular & Cellular BasisStructure/function of signaling proteins in disease
OllberdingNicholasPhDCCHMCCancer EtiologyMy research examines the role of diet and energy balance in the etiology and survival of cancer and has centered on how diet may operate independently and via hormone, oxidative stress, and inflammatory-mediated pathways to influence disease risk and prognosis
PaiAhna Luise HoffPhDCCHMCCancer Etiology
PalumboJosephMDCCHMCMolecular & Cellular BasisInteractions between the hemostatic system and innate immunity effecting tumor progression; Langerhans' cell histiocytosis
PanDaoPhDCCHMCMolecular TherapeuticsHematopoietic stem cells; Mesenchymal stem/progenitor cells; Gene therapy; Human genetics; Translational research; Lysosomal storage diseases
PangQishenPhDCCHMCMolecular & Cellular BasisSignal transduction in Fanconi anemia and its evolution to leukemia.
PaquetteIanMDUCCancer EtiologyColorectal Cancer with a focus on decreasing variation surgical outcomes on a national level
PerentesisJohnMD, FAAPCCHMCMolecular TherapeuticsAcute myeloid leukemia; neuroblastoma; PNET / Ewing's sarcoma and osteosarcoma; new anticancer drug development; Phase I clinical trials; Molecular etiology and pharmacogenetics of pediatric cancers; Down syndrome-associated leukemia; new anticancer drug development
PinneySusanPhDUCCancer EtiologyCancer epidemiology, both genetic susceptibility and traditional incidence and prevalence studies. Cancer incidence in community populations and workers exposed to ionizing radiation, nephrotoxicity in populations exposed to uranium, and health effects in populations exposed to perfluoroalkyl compounds.
PlasDavidPhDUCMolecular & Cellular BasisSignal transduction control of cancer cell metabolism and survival
PriceCarolynPhDUCMolecular & Cellular BasisTelomere structure and stability; genomic instability; DNA replication.
QiXiaoyangPhDUCMolecular TherapeuticsDevelopment of targeted, potent, broad therapeutic agents for cancer patients; preclinical studies.
RaffertyJaniceMDUCCancer EtiologyColorectal cancer (surgery)
RatnerNancyPhDCCHMCMolecular & Cellular BasisDevelopment of the nervous system; peripheral nerve tumor formation; genetic mutation in tumor suppressor genes.
ReigleBeverlyPhDUCCancer EtiologyExercise; Exercise Self-Efficacy; Functional Ability Assessment; Quality of Life; Cancer Survivorship.
SaalHowardMDCCHMCCancer EtiologyDiGeorge syndrome (22Q-VCFS); Craniofacial disorders, clinical genetics, growth disorders.
SamyRaviMDUCCancer EtiologyOtolaryngologist; director of the Adult Cochlear Implantation Program at UCMC; cochlear and auditory brainstem implantation as well as acoustic neuromas, neurofibromatosis type 2, facial nerve tumors and other diseases and disorders of the lateral skull base; use of surgical robotic systems or synthetic biology in the form of bacterial robotics systems.
SasakiAtsuoPhDUCMolecular & Cellular BasisMAP kinase, PI3Kinase/AKT pathways in regulation of cell growth and cancer progression; Akt/PKB as therapeutic target for treatment of cancer.
SchauerDanielMD, MScUCCancer EtiologyDevelopment of Patient-specific Decision Support Tools to Optimize the Use of Specific Therapies, Obesity
SeibelWilliamPhDCCHMCMolecular TherapeuticsSmall molecule drug discovery
StambrookPeterPhDUCMolecular & Cellular BasisGene therapy approach to head and neck cancer
StarczynowskiDanielPhDCCHMCMolecular & Cellular BasisRole of transcription factors in B-cell lymphomas
StarnesSandraMDUCMolecular TherapeuticsMolecular predictors of lung cancer recurrence
StewardDavidMDUCCancer EtiologyThyroid carcinoma
TalaskaGlennPhDUCCancer EtiologyIndustrial hygiene, genetic toxicology, biological monitoring, cytogenetics, chemical carcinogens and carcinogenesis.
TaraporePheruzaPhDUCMolecular & Cellular BasisRNA therapies to target advanced prostate and ovarian cancers, and to develop more sensitive and specific bio-imaging agents; Strategies to engineer (RNA) delivery vehicle and couple it with the therapeutic components to increase efficiency of delivery.
ThompsonThomasPhDUCMolecular & Cellular BasisOur lab focuses on structure/function of TGFbeta superfamily signaling, which is prominent in a number of cancers and being targeted therapeutically. A recent focus is on inhibitors to BMP ligands, which when misregulated, can reactivate cancer stem cells in the bone and lung.
TsevatJoelMD, MPHUCCancer EtiologyHealth-related Quality of Life Assessment.
van der LooJohannesPhDCCHMCMolecular & Cellular BasisDevelopment, scale-up and clinical production of viral vectors and cellular products
von AllmenDanielMDCCHMCCancer EtiologyPediatric surgical oncology; pediatric inflammatory bowel disease; surgical innovation; surgical robotics
WaggonerStephen NoelPhDCCHMCMolecular & Cellular BasisWe are focused on the responses of NK cells as both direct mediators of antiviral and antitumor effectors, as well as in their capacity as regulators of adaptive immunity
WaltzSusanPhDUCMolecular & Cellular BasisMechanisms regulating cancer growth and metastasis, and inflammation; Ron signaling pathway as a novel therapeutic target in the regulation of cancer.
WangShao-ChunPhDUCMolecular & Cellular BasisSpecial research interests include receptor tyrosine kinases, cell proliferation, development, and cancer.
WangJiangMD, PhDUCMolecular TherapeuticsSurgical pathology, GI/ Liver pathology, Transplant pathology, Cytopathology
WeberGeorgMD, PhDUCMolecular TherapeuticsPhysiologic role of metastasis genes as stress response genes; new venues for diagnosis and therapy of cancer progression.
WellsSusannePhDCCHMCMolecular & Cellular BasisHPV E6/E7 oncogenes as potential risk factors for HPV infection and transformation; analyses of primary, transformed and 3D cell culture systems; and mouse tumor models
WhitsettJeffreyMDCCHMCMolecular & Cellular BasisCystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy 
Wikenheiser-BKathrynMD, PhDCCHMCMolecular & Cellular BasisPulmonary pathology; pediatric and adult lung cancer
WuJianqiangMD, MSCCHMCMolecular & Cellular BasisPreclinical therapeutic trial on neurofibroma; Cancer stem cell(s) in neurofibroma
WuTianyingMD, PhDUCCancer EtiologyMolecular epidemiology in relation to cancer and cardiovascular disease and other chronic disease
XiaYingPhDUCMolecular & Cellular BasisSignaling mechanisms in tissue development and developmental toxicity of exposure to environmental chemicals using genetically modified mice and embryonic stem cells model systems.
XinMeiPhDCCHMCMolecular & Cellular BasisCardiovascular development; Heart growth and regeneration; Cardiomyocyte proliferation.
YadavJagjitPhDUCCancer EtiologyMicrobial pathogenesis and toxicogenomic research as related to environmental health; respiratory pathogenesis; pulmonary toxicity; xenobiotic metabolism/detoxification of environmental carcinogens and toxicants.
ZhangXiaotingPhDUCMolecular & Cellular BasisMechanisms of transcriptional and epigenetic regulation of gene expression in breast cancer and development of RNA-based nanotherapuetics.
ZhengYiPhDCCHMCMolecular & Cellular BasisLeukemia, hematopoietic stem cells, and signaling pathways dysregulated in cancer; hematopoiesis, neurogenesis, lung cancer development and small intestinal stem cell regulations; small molecule inhibitors targeting Rho GTPase signaling modules and pathologic functions in cancer and blood diseases

Associate Members:

LastFirstDegreeAffiliationProgramResearch Interests
BogdanovVladimirPhDUCMolecular & Cellular BasisPancreatic cancer; blood coagulation system and metastatic spread; integrin signaling and cancer growth; role of stromal monocytes in tumor progression.
CollinsMargaretMDUCMolecular & Cellular BasisThe Ron Receptor/Chemokine Axis in Prostate Cancer
ConfortiLauraPhDUCMolecular & Cellular BasisIon Channels and Membrane Mechanisms Regulating the Function of Human T Lymphocytes; role of Ion Channels in T Cell Response and Adaptation to Changes in the Microenvironment.
CorreaZeliaMD, PhDUCMolecular TherapeuticsOcular Oncology
DavisBradleyMDUCCancer EtiologyColorectal Cancer (Surgery)
DeFoorWilliamMD, MPHCCHMCCancer EtiologyModulation of apoptosis in cryptorchidism (undescended testes) with anti-oxidant pharmacotherapy; genitourinary complications.
DeWireMarikoMDCCHMCMolecular TherapeuticsMolecular targeted therapy, developmental therapeutics, clinical trial development and quality of life among pediatric brain tumors
DixonBradleyMDCCHMCMolecular & Cellular BasisEffect of renal microenvironment on DNA damage response pathway to understand the susceptibility of GI tissues used in bladder reconstruction to carcinogenesis; cystic kidney diseases
Elnakat ThomasHalaPhDUCMolecular & Cellular BasisPI3K/mTOR signaling and cancer growth
FergusonMarthaMDUCCancer EtiologyColorectal Cancer
GaitondeKrishnanathMDUCMolecular & Cellular BasisStem cells, hematopoietic stem cells, mobilization of stem cells, stem cell aging, aging associated leukemia
GuoFuKunPhDCCHMCMolecular & Cellular BasisRole of intracellular signal transducers in development of cancer; T and B lymphocyte development and function
Hashemi-SadraeiNooshinMDUCMolecular TherapeuticsLung, head and neck cancer; DNA repair and autophagy
HugoEricPhDUCMolecular & Cellular BasisCatecholamine signaling in adipose tissue and breast cancer, extrapituitary prolactin, Bisphenol A and obesity
JiHongPhDCCHMCMolecular & Cellular BasisDirector of the Pyrosequencing Core Laboratory for Genomic and Epigenomic Analysis
KleeneStevenPhDUCMolecular & Cellular BasisPrimary celia and role of celiary channels in cancer, obesity and renal disease.
KomoroskiRichardPhDUCMolecular & Cellular BasisNMR of phospholipids in prostate cancer
KumarAshishMD, PhDCCHMCMolecular & Cellular BasisChildhood cancer and blood disorders; immune deficiency; Biology of infant leukemia
LaneAdamPhDCCHMCMolecular & Cellular BasisNovel statistical methods in the areas of adaptive and optimal experimental designs with applications to phase I and phase II clinical trials.
MastT DouglasPhDUCMolecular TherapeuticsUltrasound therapy and imaging for cancer treatment, including image-guided thermal ablation by ultrasound echo decorrelation imaging.
McCullumsmithCherylMD,PhDUCCancer EtiologyConsultation-liaison psychiatry and suicide research, interest is in examining mood and suicidality in this context, as well as other psychiatric factors impacting outcomes
MercerCarolPhDUCMolecular & Cellular BasisFocused on the regulation and effectors of the mTOR signaling pathway and their significance in cancer and cell biology.
MierzwaMichelleMDUCMolecular TherapeuticsClinical and translational head and neck cancer/GI cancer research
MoncrieffeHalimaBSc, PhDCCHMCMolecular & Cellular BasisMechanisms of immune system suppression with specific interest in regulatory T cell function; Immunoregulation; juvenile idiopathic arthritis; biomarkers of response to medication.
MullinsKimMSNUCCancer EtiologyClinical Nursing in oncology hematology care
MyersMelaniePhDCCHMCCancer EtiologyInterested in population-specific applications of genomic information and technologies, family history as a risk assessment tool, as well as applications of genetic technologies to better estimate cancer risk. I am also interested in behavioral responses to cancer risk among those at increased risk of inherited cancer susceptibility.
Privette-VinnedgeLisaPhDCCHMCMolecular & Cellular BasisRole of cancer oncogene (DEK) in regualtion of breast cancer tumorigenicity; DNA damage and repair.
SmithrudDavidPhDUCMolecular TherapeuticsDevelopment of anti-cancer agents based on the design and synthesis of low molecular weight compounds that act as drugs or sensors.
SnyderJonathanMDUCCancer EtiologyColorectal Cancer (Surgery), minimally invasive surgery;
SumegiJanosMD, PhDCCHMCMolecular & Cellular BasisLymphoproliferative disease; hemophagocytic lymphohistiocytosis; usher syndrome
TamNevillePhDUCMolecular & Cellular BasisMy primary research interest is to understand how sex hormones, diet and environment contribute to prostate carcinogenesis, with a focus on the role of physiological/dietary/environmental estrogens in the initiation and progression of prostate cancer.
Wise-DraperTrishaMD, PhDUCMolecular TherapeuticsOur lab is primarily focused on innovative therapies for advanced head and neck squamous cell carcinomas
ZhangXiangPhDUCMolecular & Cellular BasisWith extensive bench lab experience in the field of genomics and epigenomics. He is interested in the next generation sequencing, which is an exciting and fast-moving area in biomedical research. As the Director of the Genomics, Epigenomics and Sequencing Core ( since 2012, Dr. Zhang is committed to serve investigators by providing high quality data and timely completion of their projects, and also developing new services for the Core.
ZhangYuhangPhDUCMolecular & Cellular BasisCell-cell signaling mechanisms controlling development, growth and regeneration of mouse skin and skin appendages. Molecular mechanisms underlying epithelial-melanocyte communication and the potential to reveal novel therapeutic targets for disorders of skin including melanoma.